Job Description

Required Skills & Experience

-PhD or equivalent in histopathology, immunology or cellular and molecular biology or MS degree + at least 3 years of direct experience in a molecular and imaging histology lab, or BS degree + at least 10 years of direct experience in a molecular and imaging histology lab

-Strong skillset in histotechniques (tissue processing and embedding, paraffin and cryo sectioning, special stains, automated immunohistochemistry and in situ hybridization using Ventana Discovery Ultra or similar platform, whole slide scanning using Zeiss AxioScan or similar)

- Extensive practical experience in experimental design (i.e. validation of antibodies), execution (i.e. applying validated antibody to tissue) and data analysis (i.e. imaging)

-Clearly record and organize in electronic lab notebooks and shared drives

Nice to Have Skills & Experience

-Experience working with human and murine brain, liver, lung, kidney, and/or joint tissues

-Cell and tissue culture experience. Candidates with Precision Cut Tissue Slice experience using human and animal tissue highly preferred.

-Hands on working experience with novel molecular histology techniques (i.e. RNAscope, spatial transcriptomics)

Job Description

One of our large pharmaceutical clients is a actively looking to hire a Molecular Histologist with strong expertise in advanced histotechniques and quantitative image analysis to join their team. The successful candidate will perform molecular and imaging histology work across multiple therapeutic areas with primary emphasis on projects related to neurodegenerative, neuroinflammatory, renal, and liver diseases. Molecular and imaging histological technology is currently used to validate novel human genetic targets, to understand their mechanisms of action, and to confirm target engagement and the effects on disease phenotypes of biological or chemical molecules in healthy and disease relevant tissues. The scientist will join a team with expertise in cutting-edge technologies including human and animal precision cut tissue slice (PCTS) culture, molecular histology, complex in-vitro, ex-vivo, and in vivo models, high content imaging, etc. A collegial environment provides the candidate with the opportunity to interact with internal experts from multiple disciplines e.g. AI/ML, statistics, etc. These interactions will facilitate the design, execution, and analysis of tissue biology experiments to support the preclinical phase of drug development. As a molecular and imaging histologist, one of your major roles will be to interact with project teams and leaders and identify how histotechniques can support target validation and drug development. A second major role is to design, perform and analyze histology studies in support of projects and deliver results to the team according previously agreed timelines.

Responsibilities:

- Use a broad knowledge of histotechnique (including but not limited to microtomy, cryotomy,

brightfield and fluorescent microscopy, automated immunohistochemistry (IHC), in situ hybridization (ISH, etc.) to develop, validate, and implement assays that address project team needs

- Develop and evaluate automated and/or machine learning (AI) algorithms using Image Analysis software (HALO, Visiopharm, etc.) to generate quantitative analytical data.

- Maximize information from imaging readouts by engaging colleagues from the AI/ML and Research Statistics teams

- Independently execute laboratory experiments, conduct statistically supported data analyses, and deliver results in a timely manner to enable informed decision making

- Clearly record in electronic lab notebooks and communicate study results at internal and external meetings

This project will last 12 months, with potential extensions.

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